| S2921 |
PF-4981517 |
PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. |
Selective |
CYP3A4, IC50: 30 nM |
| S2900 |
Cobicistat (GS-9350) |
Cobicistat (GS-9350) is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM. |
Selective |
CYP3A, IC50: 30 nM-285 nM |
| S2555 |
Clarithromycin |
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor. |
Selective |
|
| S2476 |
Itraconazole |
Itraconazole is a relatively potent inhibitor of CYP3A4, used as a triazole antifungal agent. |
Selective |
|
| S2344 |
Piperine |
Piperine (1-Piperoylpiperidine) is the alkaloid responsible for the pungency of black pepper and long pepper, which has also been used in some forms of traditional medicine and as an insecticide. |
Selective |
|
| S2046 |
Pioglitazone HCl |
Pioglitazone HCl is a hydrochloride salt form of pioglitazone which is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor for CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 μM, 11.8 μM and 32.1 μM, respectively. |
Pan |
CYP3A4, Ki: 11.8 μM |
